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Health & Beauty - E: <a href="mailto:kensington@myvillage.co.uk">kensington@myvillage.co.uk</a></b></font></td>
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<td valign="top" colspan="2" bgcolor="#990033"><font color="#FFFFFF"><b><font size="1"><a name="aspirin"></a>Aspirin
May Lower Cancer Risk </font></b><font size="1">- 08/03/01</font></font></td>
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<p><font size="1">Women who take aspirin at least three times a week
for an extended period may decrease their risk of ovarian cancer
by as much as 40 percent, a new study shows. </font></p>
<p><font size="1">The study's findings parallel previous studies on
the preventative powers of aspirin for heart disease and cancers
that begin in the colon or rectum. However, women should realize
that long-term use carries risks, including ulcers, says the lead
author, Dr. Arslan Akhmedkhanov of New York University School of
Medicine. </font></p>
<p><font size="1">The study, funded by the National Institutes of
Health and released Wednesday at the annual meeting of the Society
of Gynecologic Oncologists, suggests that regular aspirin use for
at least six months reduces the risk of epithelial ovarian cancer.
Epithelial ovarian cancer, the most common ovarian cancer, originates
in the cells that cover the surface of a woman's ovary. </font></p>
<p><font size="1">Akhmed Khanov said his team's research could affect
the treatment and prevention of gynecologic cancers but that more
research is needed. He studied aspirin - an anti-inflammatory -
because chronic inflammation could be related to epithelial ovarian
cancer, as it is in endometriosis and pelvic inflammatorydisease.
</font></p>
<p><font size="1">The study involved 748 women enrolled in the New
York University Women's Health Study who answered questions about
their aspirin use from 1994 to 1996. Of those, 68 developed epithelial
ovarian cancer. Among the cancer patients, 10 percent had used aspirin
regularly. Among the rest, 16 percent reported regular aspirin use.
</font></p>
<p><font size="1">The researcher said that after accountings for variables
such as contraceptive use and family cancer history, he calculated
that regular aspirin use could reduce the risk of developing the
cancer by 40 percent. The study was the fifth on the relationship
between ovarian cancer and aspirin or other nonsteroidal anti-inflammatory
drugs. Akhmedkhanov said his was the first to begin with healthy
participants who were followed over time, a research method considered
more accurate than a retrospective study. </font></p>
<p><font size="1">Akhmedkhanov's study is intriguing, said Dr. Raymond
DuBois, director for gastroenterology at Vanderbilt University Medical
Center in Nashville, who has researched aspirin's relationship to
colon cancer. ``We definitely see a 50 percent reduction in risk
of colon cancer with aspirin use, and it's exciting to see a relationship
being established for other types of cancer,'' DuBois said. </font></p>
<p><font size="1">Dr. Beth Karlan, director of gynecologic oncology
at Cedars-Sinai Medical Center in Los Angeles, called the study
provocative and worthy of further study but not definitive because
of the small number of patients. ``The data so far cannot lead me
as a clinician to recommend it to my patients,'' she said. Physicians
stress a low-fat diet, regular exercise and avoidance of alcohol
and tobacco as the best prevention for most cancers. Birth control
pill use also has been documented as lowering risks of ovarian cancer.
</font></p>
<p><font size="1">Ovarian cancer is the sixth most common cancer in
women. According to the American Cancer Society, more than 23,000
American women will be diagnosed with the disease this year and
about 14,000 - nearly 61 percent - will die. Because symptoms are
subtle, most cases of ovarian cancer are diagnosed only after they
reach advanced stages. </font></p>
<p><font size="1">On the Net:<br>
</font><font size="1"><a href="http://www.sgo.org/"><b>Society of
Gynecologic Oncologists<br>
</b></a></font><font size="1"><a href="http://www.cancer.org/"><b>American
Cancer Society</b></a></font></p>
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